Rufinamide: treatment of seizures associated with Lennox-Gastaut syndrome
نویسندگان
چکیده
منابع مشابه
Treatment of Adults with Lennox–Gastaut Syndrome: Further Analysis of Efficacy and Safety/Tolerability of Rufinamide
INTRODUCTION Management of Lennox-Gastaut syndrome (LGS) in adulthood can be particularly challenging. Published reports describing the use of rufinamide specifically in adult patients with LGS are scarce. A post hoc subgroup analysis of data from a phase III trial was conducted to investigate the efficacy and safety/tolerability of rufinamide in adults with LGS. METHODS A randomized, double-...
متن کاملRufinamide as an adjuvant treatment in children with Lennox-Gastaut syndrome
PURPOSE To evaluate the efficacy of rufinamide as an add-on treatment in children and adolescents with Lennox-Gastaut syndrome (LGS). METHODS The study was an open-label, observational clinical trial of rufinamide as an add-on treatment in intractable LGS patients. This intent-to-treat trial included 4 weeks of scheduled titrated doses and a 12-week maintenance phase with a target dose of 20-...
متن کاملRufinamide for the treatment of Lennox-Gastaut syndrome: evidence from clinical trials and clinical practice.
Rufinamide was granted orphan drug status in 2004 for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in patients aged ≥4 years, and was subsequently approved for this indication in several countries, including Europe and the United States. Structurally unrelated to other antiepileptic drugs, rufinamide is thought to act primarily by prolonging the inactivation phas...
متن کاملUpdate on the management of Lennox-Gastaut syndrome with a focus on rufinamide
OBJECTIVE This review summarizes the treatment of Lennox-Gastaut syndrome, an intractable epileptic encephalopathy of early childhood. In particular, the review focuses on rufinamide, a recently released anticonvulsant medication with reported effectiveness in this epilepsy syndrome. METHODS A systematic literature search (PubMed) was performed to review the existing literature pertaining to ...
متن کاملlennox-Gastaut syndrome: an updateon treatment.
Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy. Few current treatment options are effective in improving seizure control. This paper reviews the available treatments of LGS and discusses a new option in Canada, rufinamide. It is a wide spectrum anticonvulsant, approved in a number of countries for the treatment of LGS. In a randomized controlled trial in the LGS population, ...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2014
ISSN: 2319-2003
DOI: 10.5455/2319-2003.ijbcp20141230